Abstract: Objective:The aim of this research is to study the central mechanism of exercise-induced fatigue by the observation of rats' ECoG during and after exhaustive exercise.Methods:To record the ECoG of rats during the development and recovery of exercise-induced fatigue by the Electrophysiologic method and analyze the changes of power spectrum,frequency spectrum characters of ECoG.Results:In exercise condition,the total power of ECoG power spectrum was significantly higher than that of rest condition(P<0.05) and the main energy distribution of ECoG frequency was 6⁹ Hz;There is significantly difference of ECoG frequency distribution between exercises with and without fatigue(P<0.05).The δ wave increased and the α wave decreased(P<0.05);Also,significant difference of ECoG frequency distribution existed between before and immediately after exhaustive exercise(P<0.05).As the δ wave increased and the θ wave decreased(P<0.05).However,the ECoG frequency distribution recover to that of pre-exercise in 30 minutes of recovery time;The gravity frequency of ECoG continuously decreased during the exhaustive exercise and significantly difference occurred when the rats exhausted(P<0.05),Whereas,it recover back to pre-exercise level in 30 minutes of recovery time.Conclusion:The development of exercise-induced central fatigue is a gradually accumulative process.Both the development and formation of central fatigue during exercise are with the δ wave increase in ECoG.The result indicated that the increase of δ wave may be an important central mechanism of exercise-induced fatigue.However,the changes of ECoG caused by exhaustive exercise could recovery soon after exhaust.