Abstract: Objective:ECG and BP abnormalities in the exercise are the most simple and effective indicators to predicate exercise risk.The aim of the study was to do correlation and regression analysis for the ECG and BP in exercise and the physiological and biochemical indexes in the40 ⁴9yr adults who had the exercise risk, then to set up the cardiovascular risk prediction index system for Chinese adults.Methods:173men and 174women who were 40⁴9yr were tested by graded exercise test, the ECG and BP was monitored in test;When ST-segment under pressure≥0.1mV or SBP down>10mmHg during the exercise, the adults had ECG or BP abnormalities.ST-segment under pressure values or SBP down values' relations with quiet physiological and biochemical indicators and the establishment of ECG and blood pressure prediction formula were analyzed by multiple regression analysis and stepwise regression analysis.Results:1) The normal ST-segment under pressure values had significant association with LDH1, LDH1/LDH, OP and PA, also set up the formula to predicate the normal ST-segment under pressure values for adult men in exercise;The abnormal ST-segment under pressure values had significant association with HDL-c, OP and DBP, also set up the formula to predicate the abnormal ST-segment under pressure values for adult men in exercise.2) The normal STsegment under pressure values had significant association with BMI and LF/HF, also set up the formula to predicate the normal ST-segment under pressure values for adult women in exercise;The abnormal ST-segment under pressure values had significant association with OP, Resting HR, CKMB and AST, also set up the formula to predicate the abnormal ST-segment under pressure values for adult women in exercise.3) Men and women abnormal BP had analysis together because of a little people with abnormal BP;The abnormal SBP down values had significant association with PWV, PA and LDH1/LDH, also set up the formula to predicate the abnormal SBP down values for adults.Conclusions:1) 40⁴9yr men and women arise myocardial ischemia and blood pressure drop when load increases during exercise.2) Myocardial ischemia and blood pressure drop when load increases through exercise for 40⁴9yr men and women can be predicted by resting physiological and biochemical tests.