Abstract: This paper studies the effects of EcoRI and XbaI polymorphisms of apolipoprotein B gene on the treatment of dyslipidemia through exercise.The subjects were middle-aged people with dyslipidemia.First of all,the cardiac functional capacity(F.C.)was measured using graded exercise testing.After that,the exercise prescription was drawn up.The exercise intensity was at the level of 50% ~70% F.C.and the duration were 30 to 60 minutes.The improvement in serum lipids profile after applying exercise prescription was observed and the effect of apolipoprotein B gene polymorphism on the treatment of dyslipidemia through exercise interventions was probed into.The results show that EcoRI and XbaI polymorphisms of apolipoprotein B gene can influence the effect of exercise interventions on dyslipidemia treatment,which mainly appears as the difference in the improvement of serum HDL-C level after exercise interventions.For those individuals with E2E2 or X1X2 genotypes,their serum HDL-C level improved after aerobic exercise interventions.However,there was no change in serum HDL-C level of those individuals with E1E1,E1E2 or X1X1 genotypes.For those individuals with both E2E2 and X1X1 genotypes,aerobic exercise interventions still can improve serum HDL-C level.Nevertheless,for those individuals with both E1E2 and X1X1 genotypes,aerobic exercise interventions can not make an improvement in serum HDL-C level.These results designate that the differentiations of EcoRI and XbaI polymorphisms of apolipoprotein B will result in different effects of exercise interventions on blood lipids.