Abstract: Through using the method of literature review,this paper summarizes the status quo of the research on oxidative stress in cardiovascular and exercise on the basis of reactive oxygen species-mediated oxidative stress,analyzes the hot researches of reactive oxygen species-mediated oxidative stress damage and protection mechanisms in cardiac,and probes into the relationship between cardiac damage and protection induced by reactive oxygen species-mediated oxidative stress,and the factors which affect reactive oxygen species' balance in stress,indicating that mitophagy sheds a new light on researches of cardioprotection mechanism in exercise.