Abstract: This paper is aimed to observe the effect of aerobic exercise and resistance exercise on the chronic inflammation of obese youth.37 volunteers are divided into aerobic exercise group(mail-10,female-10,21.1±2.0years,BMI=30.28± 2.17)and resistance exercise group(mail-8,female-9,21.1±1.6years,BMI=30.10±2.35).All the volunteers had taken 4weeks exercise,6days per week and 1.5 hours per day.The mode of the aerobic exercise group is jogging with the individual heart rate to monitor the intensity.While the aim of resistance exercise group is to build muscle by using own body weight or Thera-band.The diet of the volunteers is designed by the resting metabolic rate of themselves.All the volunteers were taken 3times dual energy X-ray testing and drawn 3times venous blood before exercise,after4 weeks and 8weeks later to test the concentration of TNF-αand Visfatin with ELISA.The results show that the body weight of aerobic exercise group significantly decreased from 92.13±13.68 kg to 84.08±11.90kg(P<0.01)after 4 weeks.The body weight of resistance exercise group significant decreased from 86.68±13.91 kg to 79.79 ±11.82kg(P<0.01)after 4weeks.There exists the same change in body fat rate.The fat% decreased from 38.84± 5.54% to 34.65±6.31%(P<0.01)after 4weeks and continued decreased to 33.99±7.33% after 8weeks in aerobic exercise group.The fat% decreased from 38.52±5.41% to34.30±6.91% %(P<0.01)after 4weeks and continued decreased to 33.10±6.82% after 8weeks in resistance exercise group.The concentration of TNF-αdecreased from 16.60±2.22 U/ml to 16.20±1.65 U/ml after 4weeks,but there is no significant difference,while significantly decreased to 14.13±1.82 U/ml(P<0.01)after 8 weeks in aerobic exercise group.The concentration of TNF-αincreased from 16.29± 2.55μg/ml to 16.77±2.82U/ml after 4 weeks,but there is no significant difference,while significantly decreased to 14.93±2.48 U/ml(P<0.01)after 8 weeks in resistance exercise group.The concentration of Visfatin significantly decreased from 24.58±11.14mg/L to 10.35±6.46mg/L(P<0.01)after 4weeks,but significantly increased to 19.66±8.64mg/L(P<0.01)after 8weeks in aerobic exercise group.The concentration of Visfatin significantly decreased from 23.45±14.13 mg/L to 16.07±14.32mg/L(P<0.01)after 4weeks and remained at 17.40±9.98mg/L after 8weeks in resistance exercise group.It can be conclude that the body weight will be decreased by reduce the body fat rate in aerobic and resistance exercise groups,and the chronic inflammation state of obese youth will be better through the reducing of the concentration of TNF-αand Visfatin by exercise with the effect of resistance exercise is better than aerobic exercise.