Abstract: As an auxiliary rehabilitation approach, moderate aerobic exercise has shown satisfactory benefits in assisted detoxification, relief of abstinence syndrome, and inhibition of relapse, which is considered relatively safe and green. There are a few studies including clinical trials and animal experiments available in the field of addiction medicine about physical exercise intervention for druginduced or stress-induced psychological craving and relapse, however, the potential neurobiological mechanisms have not been fully understood yet. Present research suggest that the effectiveness of physical exercise intervention for relapse may be achieved through the regulation of dopamine and its receptors, regulation of noradrenaline and glucocorticoids, and regulation of endogenous opioid peptides. Objectively analyzing existing hypotheses and mechanisms not only can provide a more complete theoretical basis about physical exercise intervention for relapse, but also can clarify the insufficiency of previous research and prospect of the future research directions.