Abstract: Objective: To evaluate the clinical effect of weight lose training on patients after anterior cruciate ligament reconstruction by meta-analysis. Methods: The randomized control trials on the clinical efficacy of weight lose training on patients after anterior cruciate ligament reconstruction were searched in Pub Med, Web Of Science, The Cochrane Library, Embase, CNKI, Wanfang, and Weipu databases, and two researchers independently screened the literatures according to the inclusion and exclusion criteria. A total of 6 randomized control trials with 395 patients were included in this study. After anterior cruciate ligament reconstruction, the weight lose group received conventional rehabilitation training combined with weight lose training, and the control group received conventional rehabilitation training only. The Meta-analysis was performed using Revman 5.3 software. Results: 1) The IKDC score of the weight lose group was significantly higher than that of control group at 3 months after surgery MD=7.96, 95% CI(6.04, 9.89), P<0.000 01, but there was no significant difference between the two groups and at 6 months after surgery MD=4.88, 95% CI(-1.27, 11.02), P=0.12; 2) The Lysholm score of the weight lose group were higher than those of control group at 1 month after surgery MD=7.85, 95% CI(6.79, 8.91), P=0.02 and 3 months after surgery MD=7.38, 95% CI(6.39, 8.38), P<0.00001; 3) The joint range of motion of the weight lose group was better than that of control group MD=3.09, 95% CI(1.13, 5.06), P=0.002; 4) The i EMG of the weight lose group was better than the control group MD=1.40, 95% CI(0.68, 2.12), P=0.0001; 5) The T2value of the tendon-bone node in the weight lose group was better than that of the control group at 3 months after surgery MD=-15.41, 95% CI(-18.73,-12.09), P<0.000 01; 6) The signal intensity of the weight lose group was better than that of the control group at 1 month after surgery MD=0.85, 95% CI(0.69, 1.01), P<0.000 01; 7) The passive position sense of the weight lose group was better than that of control group at 0°~40° MD=-0.55, 95% CI(-0.77,-0.33), P<0.000 01, 40°~80° MD=-0.59, 95% CI(-0.81,-0.38), P<0.000 01, and 80° ~120° MD=-0.57, 95% CI(-0.78,-0.37), P<0.000 01. Conclusion: Compared with conventional rehabilitation training, weight lose training is more effectively improve the knee function such as ROM and proprioception subjective function score, and the imaging performance is also better. Limited by the number and quality of included studies, this conclusion needs to be verified by more high-quality studies.