Abstract: Exercise prescription is the key part in the implementation of the physical-medical integration model. Currently, the theoretical framework of exercise prescription formulation has improved; however, the applicability, safety and effectiveness are core factors that limit the widespread application of exercise prescription in clinical practice. To address these issues, the study proposes several strategies: 1) Improve the pre-exercise health evaluation system so as to expand the clinical application of exercise prescriptions; 2) clinical exercise tests should be used to ensure the safety of exercise prescription; 3) optimize the effectiveness of exercise prescription by formulating periodic evidence-informed exercise prescription.