Abstract: Based on the theoretical framework and knowledge system of ICF, this study aimed to construct the theoretical framework of rehabilitation physical exercise and design corresponding exercise program for severely disabled people. Methods: Firstly, the physical activity function and rehabilitation physical needs of 201 severely disabled persons were surveyed by using self-designed questionnaire in Weifang and Suzhou; and then, 26 severely disabled persons were randomly recruited to carry out rehabilitation physical exercise intervention for 12 weeks, the feasibility and effectiveness of the exercise program was analyzed. Results: The 12-week rehabilitation physical exercise improved the waist circumference, vital capacity, muscle strength, range of motion of most joints, spasm, balance and coordination ability in severely disabled persons(P<0.05). The overall disability level of activity and participation were improved also(P<0.05). In addition, the improvement effect on the physiological, psychological and environmental aspects of qOL as well as the overall subjective feeling of qOL and health status were improved(P<0.05). The life satisfaction score was significantly increased(P<0.05). Conclusion: The home-based rehabilitation physical exercise program designed in this study is feasible in practice, and it has certain effects on improving the overall function of the disabled.