Abstract: Epigenetics study the mechanism of gene expression changes caused by en-vironmental factors.These changes don't link with the changes of gene sequences,a-nd mostly caused by the changes of DNA methylation and histone modification through environmental factors.The epigenetic mechanism is the inner cause of Alzheimer's disease(AD).Studies have shown that exercise can improve related physiological and biochemical indexes,and alleviate the pathological process of AD;but there was few report on the epigenetic mechanism of exercise intervention in AD research.Starting from the present situation of AD,the pathogenesis,epigenetics,exercise interventionresearch,this paper makes a comprehensive analysis on AD and analyzes the epigenet-ic mechanism of exercise intervention in AD.It provides a new perspective of epigen-etics to exercise intervention of AD research and sports science research.