Association between ACE Gene I/D Polymorphism and the Effects of Living High-Exercise High-Training Low on the Cardiac Functions

To explore the association between Insertion/Deletion polymorphism of the angiotensin converting enzyme(ACE) gene and the effects of living high-exercise high-training Low(HiHiLo) on the cardiac structure and functions.76 healthy men of Han nationality in northern China underwent HiHiLo training for 4 weeks.Training program was as follows:exposure in hypoxic environment(14.5%¹4.8%O₂,10 h/day),three times hypoxic training per week(15.4%O₂),and training at sea level.The structure and function of left ventricle were measured before and after the protocol,and the ACE gene I/D polymorphism was detected by PCR.The findings indicated that LVM,LVMI,IVSD and PWD all increased significantly after training(P<0.05).The EDV,EF,SV,SVI and E/A were increased significantly at rest,all loads and recovery after training(P<0.05),but the HR,CO,COI,Vmn and Vp were decreased significantly at rest,all loads and recovery after training(P<0.05).No significant differences were in all baseline index before HiHiLo among groups,and no significant differences were observed in other index after HiHiLo among groups except HR at 50 W load and 150 W load(P<0.01).The present study suggested that the structure and function of left ventricle were improved through HiHiLo.No association exists between ACE gene I/D polymorphism and individual cardiac contracted functions response to HiHiLo.