The Relationship between FTO Gene Expression and Food Intake by Endurance Training in Rats

Objective:To investigate the relationship between FTO gene expression and intake food by endurance training in rats.Methods:The rats were randomly divided into control and endurance trained group.This paper analyzed the mRNA expression of FTO in liver and skeletal muscle,adipose tissue and hypothalamus,body weight,adipose tissue weight around kidney and epididymis,average food intake per day in rats after 12 week unload swimming training.Results:The FTO gene mRNA expressions in skeletal muscle,adipose tissue and hypothalamus were higher than in liver,its expression in hypothalamus was higher than in skeletal muscle and adipose tissue,but its expression in skeletal muscle and adipose tissue was no significant different.Endurance training up-regulated FTO gene expression in hypothalamus,however,there was no change in skeletal muscle,liver and adipose tissue.The rat weight was no significant different in parallel time point,but food intake significantly increased in trained rats.Adipose tissue weight around kidney and epididymis decreased significantly in trained rats.Conclusion:Endurance training increased the FTO gene expression in hypothalamus which stimulated more food intake.However,the rat weight was no change for exercise expending more energy.