Cell Signaling for Exercise-Induced Adaptation:ARole Transition of Mitochondria

Mitochondria is not only a eukaryotic cell energy plant,but also the regulation center of cell signal transduction.It is important to convert the traditional mitochondrial function and explore the crosstalk of mitochondrial energy metabolism and signal transduction for revealing the theory of adaption of physical activity.It is the abnormal symbiotic relationship between mitochondria and eukaryotic cells that may inducepathologyof many chronic diseases.That is,the trade of energy for food is retarded.The effect of exercise on mitochondrial quality control involves not onlymitochondrialbiogenesis and dynamics(forward adaptation),but alsothe induction of autophagy(mitophagy).In the near future,autophagy,regarded as a"reverse adaptation",may further disclose the underlying mechanisms of Mitochondrial Quality Control,the future resultswill enrich the relationship between exercise adaption and signal regulation,and provide more understandingsfor mitochondria-related diseases.