The Effects of Aerobic Combined with Resistance Exercise on Cardiovascular Efficiency in Male Obese Adolescents and Related Mechanisms

Objective:To assess effects of exercise to oxidative stress,inflammation and endothelial function before and after exercise in male obese adolescents for investigating the possible mechanisms of exercise improving cardiovascular function.Method:26 male obese adolescents take a 6-weeks exercise intervention,the flow mediate dilation(FMD) was detected using ultrasound technique before and after exercise intervention,while the serum levels of MDA,8-isoprostane,CRP and TNF-α was testing.Results:the weight,percentage of body fat,insulin resistance showed a significant decline after 6 weeks of exercise intervention(P<0.01),and FMD was improved significantly(P<0.05),the serum MDA(P<0.01),8-isoprostane(P<0.05),CRP(P<0.05) and TNF-α(P<0.05) levels significantly decreased;the positive correlations between improved FMD and reduced the levels of MDA(r=0.497,P=0.012),8-isoprostane(r=0.677,P=0.001),CRP(r=0.489,P=0.011) as well as TNF-α(r=0.414,P=0.036) were found.Conclusion:the mechanical aerobic combined with resistance exercise improved vascular endothelial function in obese adolescents may be associated with the anti-oxidative stress and anti-inflammation.