Roles of c-microRNAs in Exercised-Induced Phenotype Change of Skeletal Muscle

miRNAs are a group of small non protein-coding RNAs that regulate target gene expression by translational repression and target mRNA degradation and affect proliferation, differentiation, hypertrophy and apoptosis of skeletal muscle.c-microRNAs refer those microRNAs from cells secreting into blood circulation, they also regulate skeletal muscle physiology and pathology conditions, including acute and chronic exercise related phenotype changes.This paper mainly focuses on skeletal muscle-specific microRNAs, c-microRNAs and their role in regulating exercise induced skeletal muscle phenotype change, and clarifies the role of c-microRNAs as biomarkers in physiological and pathological conditions.Further understanding the molecular mechanism of exercise-induced skeletal muscle phenotype changes fully will enrich the cell signal theory and pathological molecular mechanisms related muscle diseases.In addition, it can put forward new ideas for sports fatigue, sport incidence and prevention strategies related exercise-induced diseases.