Effect of L-type Calcium Channel Blocker and Exercise Training Management on Blood Pressure and Blood Lipids Status of Coronary Heart Disease Patients

Objective:To examine effect of L-type calcium channel blocker and exercise training management on blood pressure and blood lipids status of coronary heart disease patients.Methods:Thirty female coronary heart disease patients were recruited as subjects in the study.Then,according to with or without L-type calcium channel blockers management,they were subdivided into two groups,i.e.medication group(n=13)and non-medication group(n=17).After that,values of systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),rate-pressure product(RPP),and total(CHO),low-density lipoprotein(LDL),high-density lipoprotein(HDL)cholesterol levels and data on triglyceride(TG)were obtained from the patients both pre and post a 12-week exercise based rehabilitation program.Results:1)Effects of medication:The medication group showed a similar level of blood pressure to the non-medication group(P>0.05)pre the exercise training program,but its HR was significantly lower than that of the non-medication group(P<0.05).There was a non significant difference between the two groups for values of any blood lipids variables(P >0.05).2)Effects of exercise training:Compared with pre program,values of SBP,HR,RPP and CHO showed a significant decrease in non-medication group post the program(P<0.05 and P<0.01).3)Combined effects of medication and exercise training:Compared with pre program,blood lipids status,not only CHO but also TG and HDL levels improved significantly in medication group post the program(P<0.05).Conclusion:Optimal exercise training demonstrated apositive effect on blood pressure,blood lipids and myocardial oxygen consumption status improving in coronary heart disease patients.Compared with exercise alone,L-type calcium channel blocker plus exercise training management provided more benefits for blood lipids modifying in the patients.