Who’s Next?——Regulation of Skeletal Muscle Energy Metabolism by Key Signal Molecules during Exercise

Skeletal muscle is not only a most significant motive organ,but also an important place for energy metabolism.Its metabolic homeostasis is a basic precondition and important guarantee to maintain muscle's health and even the whole body's health.Exercise can domesticate the energy metabolism system of muscle,and make sure that it can experience positive adjustment and phenotypic adaptation(energy domestication)as well as produce more energy.The enrichment of molecular and cellular signal pathway theory,as well as the relocation and conversion of mitochondria offer us a new perspective for exercise-induced adaptation of muscle energy metabolism.As the most sensitive receptors or regulators of energy state,key signal molecules such as AMPK,mTOR,PGC-1α,p53,SIRT1,FoxOs as well as their signal network are very crucial to maintain muscle energy metabolism.exploring more key signal molecules and analyzing their signal coupling mechanism relevant to energy metabolism and mitochondrial function network will further disclose exercise-induced adaptation of muscle energy metabolism homeostasis mechanism.