Exercise-mediated Autophagy is a Built-in Mechanism to Regulate Skeletal Muscle Metabolic Homeostasis

As a compensatory and built-in mechanism of skeletal muscle,autophagy not only could degrade reactive oxygen species,bacteria,aging or damaged organelles such as mitochondria,endoplasmic reticulum,ribosome,as well as degrade glycogen,lipid,non-functional and functional protein when suffer energy stress such as exercise,fasting,nutrition restriction and muscle contraction.Autophagy accordingly could improve muscle quality control,as well as energy and synthetic substrates for cellular renewal and metabolism.Exercise training-mediated autophagy not only could improve mitochondrial quality control,stabilize mitochondrial function network,as well as maintain metabolic homeostasis of muscle,but also effectively prevent insulin resistance,obesity,type II diabetes and some other metabolic diseases.Exercise training-mediated autophagy could also entirely adapt muscle mass and function to their items,and further improve muscle metabolism and functional homeostasis.