A Meta-analysis of Regular Aerobatic Exercise on Plasma IL-6 Level in Adults

Objective:To evaluate the effect of aerobatic exercise for plasma IL-6levels in adults.Methods:The randomized controlled trials(RCTs)of aerobatic exercise for plasma IL-6level in adults were identified from PubMed,Embase,Web of Science,Wanfang Data,CNKI and VIP Data(from inception to December,2014).The methodological quality of included RCTs was assessed by the Cochrane collaboration's tool for assessing risk of bias.The Meta analysis was performed by using STATA 13.0software.Results:Among 32 included RCTs involving 2 768adults(of them,including 670 patients with chronic inflammatory diseases),10 RCTs were graded as high methodological quality,12 graded as moderate degree,and other10 as low degree of methodological quality.The pooled result showed that aerobatic exercises were benefit to decrease plasma IL-6levels in adults,and the SMD=-0.42(95%CI:-0.62~-0.18,P=0.001),but the heterogenicity was substantive with I2=88.1%.The heterogenicity was decreased to 58.34% by adjusted for the possible bias factors such as the participants' health status,the average of age,the type of comparison between groups,the duration of aerobatic exercise and quality of study by using Meta regression.The sub-group analysis suggested that effect of aerobatic exercise decreasing plasma IL-6levels was more effective in patients with chronic inflammatory diseases or the obese individuals than the healthy adults,and SWD(95%CI)was-0.717(-1.324~-0.123,P=0.021),-0.593(-1.137~-0.05,P=0.032)and-0.189(-0.412~0.035,P=0.098),respectively.Conclusion:Current evidence shows that regular aerobatic exercises are effective to decrease plasma IL-6levels in adults,especially in patients with chronic inflammatory diseases.However,more highquality studies are required to verify the conclusion of this study due to the obvious heterogenicity and publication bias.