Mechanism of Exercise Intervention against Comorbid Depression and Diabetes——Hypothesis of Leptin Resistance

Diabetic patients with depression phenomenon is attracting more and more attention,long-term use of tricyclic antidepressants and SSRIs will increase the risk of diabetes.Exercise promotes recovery of depressive patients and patients with diabetes,but the mechanisms underlying the exercise intervention still remain unknown.For diabetes patients with co-morbid depression,focus should be on downstream of leptin signaling and leptin resistance.JAK2/STAT3 pathway is involved in leptin signaling via leptin receptor(LepRb)phosphorylation,and inflammatory cytokines(ICK)induces IKKβ/NFκB activation.JAK2/STAT3 and IKKβ/NFκB pathway are inhibited by the suppressor of cytokine signaling 3(SOCS3)in leptin resistance.Therefore,the current study puts forward that LepRb/ICK-SOCS3 pathway mediates leptin resistance in exercise intervention for comorbidity of depression and diabetes.The prospective findings may contribute to our understanding of the comorbidity between depression and diabetes,and suggest a new target or guide for pharmacological research and development against metabolic diseases.