Serum Magnesium Levels Modify the Influence of “Living High-Training Low” on Weight Loss among Overweight Adolescents

Objective:Previous studies shows that the intervention of“living high-training low”may lower body weight,and magnesium levels are inversely associated with obesity risk.However,little is known if magnesium levels modify the influence of“Living High-Training Low”on weight loss.Method:A total of 34 overweight adolescents(11~15 years of age)were enrolled and were divided into two groups;the low magnesium group(LM,below median,n=17)and the high magnesium group(HM,median and above,n=17).Within each group,participants were randomly assigned into the Living low-Training Low group or the Living HighTraining Low group.Participants in the living low-training low groups underwent exercise training in daytime and slept in regular environment,while participants in the Living HighTraining Low groups underwent exercise training in daytime and slept in hypoxia room equipped with hypoxia systems that simulated an altitude of 2 700 meters.Before and after the 4-week intervention,body composition and metabolic health-related blood biomarkers were assessed.Results:After the intervention,weight loss was observed in all 4 groups.The influences of living high training low on weight loss were greater in participants with high serum magnesium levels(11.86% ±1.10%)than that among individuals in other groups(P <0.01).Conclusions:Findings from this intervention study suggest that the influence of“Living High-Training Low”on weight loss among overweight adolescents is modified by magnesium status.This effect may be related to leptin.