A Review of Mitochondrial Dynamics in Skeletal Muscle and Cardiomyocyte Affected by Exercise——Research Prospects of Cardiac Mitochondrial Dynamics

ZHAO Yong-cai

doi:10.16469/j.css.201611009

China Sport Science > 2016 > 36(11): 75-81,96. > DOI: 10.16469/j.css.201611009

ZHAO Yong-cai. 2016: A Review of Mitochondrial Dynamics in Skeletal Muscle and Cardiomyocyte Affected by Exercise——Research Prospects of Cardiac Mitochondrial Dynamics. China Sport Science, 36(11): 75-81,96. DOI: 10.16469/j.css.201611009

Citation:

PDF (458 KB)

A Review of Mitochondrial Dynamics in Skeletal Muscle and Cardiomyocyte Affected by Exercise——Research Prospects of Cardiac Mitochondrial Dynamics

ZHAO Yong-cai

Tangshan Normal University

More Information

Received Date: November 24, 2015

Graphical Abstract

Abstract

Abstract

Mitochondria have been widely studied for their critical role in cellular metabolism,energy production and apoptosis.Mitochondrial dynamics is a research focus,and that process involves mitochondrial fusion and fission,which depend on cellular energy requirements and metabolic status.Mitochondrial fusion and fission have been observed in almost every cell type except adult cardiomyocytes,which easily develop a notion that mitochondrial dynamics is dispensable in the heart.Many studies have indicated that mitochondrial dynamics plays a crucial role in the maintenance of normal cellular homeostasis and cardiac function.Some studies investigated the effects of exercise on mitochondrial dynamics in skeletal muscle,and a few studies focused on cardiomyocytes.
- mitochondrial fission,
- mitochondrial fusion,
- skeletal muscle,
- cardiomyocyte,
- exercise

FullText(HTML)

References (56)

References

刘慧君,姜宁,赵斐,等.急性运动中骨骼肌线粒体移动相关基因表达与线粒体动力学的关系[J].天津体育学院学报,2010,25(2):118-121.

刘涛.运动对慢性心衰心肌线粒体功能、生物合成与融合分裂的调节作用[D].北京:北京体育大学,2009.

马静芬.急性运动中心肌线粒体动态变化对心肌炎症反应的影响[D].天津:天津体育学院,2014.

漆正堂,郭维,张媛,等.不同运动方式对大鼠骨骼肌线粒体融合分裂基因及Mfn2、Drp1蛋白表达的影响[J].中国运动医学杂志,2011,30(2):143-148.

孙卫东,丁虎,刘晓然,等.骨骼肌线粒体对细胞能量需求的快速应答:mfn1/2与fis1基因在急性运动中的动态表达[J].中国运动医学杂志,2008,27(5):544-550.

陶小平,彭雄辉.一次大负荷跑台运动后大鼠心肌能量代谢及线粒体形态动力学的变化研究[J].北京体育大学学报,2014,37(3):64-70.

赵永才,郑兵.运动训练对心肌线粒体途径miR-30-p53-Drp-1凋亡通路的影响[J].中国运动医学杂志,2015,34(2):128-133.

ASHRAFIAN H,DOCHERTY I,LEO V,et al.A mutation in the mitochondrial fission gene Dnm1lleads to cardiomyopathy[J].PLoS Genet,2010,6(6):el001000.

BORILLO G A,MASON M,QUIJADA P,et al.Pim-1kinase protects mitochondrial integrity in cardiomyocytes[J].Circ Res,2010,106(7):1265-1274.

CAFFIN F,PROLA A,PIQUEREAU J,et al.Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice[J].J Physiol,2013,591(23):6017-6037.

CARTONI R,L GER B,HOCK MB,et al.Mitofusins 1/2and ERRalpha expression are increased in human skeletal muscle after physical exercise[J].J Physiol,2005,567(1):349-358.

CEREGHETTI G M,STANGHERLIN A,MARTINS DE BRITO O,et al.Dephosphorylation by calcineurin regulates translocation of Drp1to mitochondria[J].Proc Natl Acad Sci,2008,105(41):15803-15808.

CHANG C R,BLACKSTONE C.Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1[J].Ann N Y Acad Sci,2010,1201(1):34-39.

CHAPPIE J S,DYDA F.Building a fission machine-structural insights into dynamin assembly and activation[J].J Cell Sci,2013,126(13):2773-2784.

CHEN L,KNOWLTON A A.Mitochondrial dynamics in heart failure[J].Congest Heart Fail,2011,17(6):257-261.

CHEN Y,LIU Y,DORN GW 2ND.Mitochondrial fusion is essential for organelle function and cardiac homeostasis[J].Circ Res,2011,109(12):1327-1331.

CHEN Y,DORN G W 2ND.PINK1-phosphorylated mitofusin2is a Parkin receptor for culling damaged mitochondria[J].Sci,2013,340(6131):471-475.

CRANE J D,DEVRIES M C,SAFDAR A,et al.The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure[J].J Gerontol A Biol Sci Med Sci,2010,65(2):119-128.

CRIBBS J T,STRACK S.Reversible phosphorylation of Drp1by cyclic AMP dependent protein kinase and calcineurin regulates mitochondrial fission and cell death[J].EMBO Rep,2007,8(10):939-944.

DIN S,MASON M,V LKERS M,et al.Pim-1preserves mitochondrial morphology by inhibiting dynamin-related protein 1translocation[J].Proc Natl Acad Sci USA,2013,110(15):5969-5974.

DING H,JIANG N,LIU H,et al.Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle[J].Biochim Biophys Acta,2010,1800(3):250-256.

DISATNIK M H,HWANG S,FERREIRA J C,et al.New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases[J].J Mol Med(Berl),2015,93(3):279-287.

DISATNIK M H,FERREIRA J C,CAMPOS J C,et al.Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction[J].J Am Heart Assoc,2013,2(5):e000461.

DORN G W 2ND,KITSIS R N.The mitochondrial dynamismmitophagy-cell death interactome:multiple roles performed by members of amitochondrial molecular ensemble[J].Circ Res,2015,116(1):167-182.

DORN G W 2ND.Mitochondrial dynamics in heart disease[J].Biochim Biophys Acta,2013,1833(1):233-241.

DORN G W 2ND,SONG M,WALSH K.Functional implications of mitofusin 2-mediated mitochondrial-SR tethering[J].J Mol Cell Cardiol,2015,78:123-128.

ESCOBAR-HENRIQUES M,ANTON F.Mechanistic perspective of mitochondrial fusion:tubulation vs.fragmentation[J].Biochim Biophys Acta,2013,1833(1):162-175.

FEALY C E,MULYA A,LAI N,et al.Exercise training decreases activation of the mitochondrial fission protein dynaminrelated protein-1in insulin-resistant human skeletal muscle.J Appl Physiol,2014,117(3):239-245.

FIGGE M T,OSIEWACZ H D,REICHERT A S.Quality control of mitochondria during aging:Is there a good and a bad side of mitochondrial dynamics[J].Bioessays,2013,35(4):314-322.

GAZIEV A I,ABDULLAEV S,PODLUTSKY A.Mitochondrial function and mitochondrial DNA maintenance with advancing age[J].Biogerontology,2014,15(5):417-438.

GREENE N P,LEE D E,BROWN J L,et al.Mitochondrial quality control,promoted by PGC-1α,is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice[J].Physiol Rep,2015,3(7):e12470.

HERN NDEZ-ALVAREZ M I,THABIT H,BURNS N,et al.Subjects with early-onset type 2diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2regulatory pathway in response to physical activity[J].Diabetes Care,2010,33(3):645-651.

IKEDA Y,SCIARRETTA S,NAGARAJAN N,et al.New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart[J].Oxid Med Cell Longev,2014,2014:210934.

IQBAL S,OSTOJIC O,SINGH K,et al.Expression of mitochondrial fission and fusion regulatory proteins in skeletal muscle during chronic use and disuse[J].Muscle Nerve,2013,48(6):963-970.

JENDRACH M,POHL S,V TH M,et al.Morpho-dynamic changes of mitochondria during ageing of human endothelial cells[J].Mech Ageing Dev,2005,126(6-7):813-821.

JIANG H K,WANG Y H,SUN L,et al.Aerobic interval training attenuates mitochondrial dysfunction in rats post-myocardial infarction:roles of mitochondrial network dynamics[J].Int J Mol Sci,2014,15(4):5304-5322.

KANG C,YEO D,JI L L.Muscle immobilization activates mitophagy and disrupts mitochondrial dynamics in mice[J].Acta Physiol(Oxf),2016,218(3):188-197.

KIM E Y,ZHANG Y,BEKETAEV I,et al.SENP5,a SUMO isopeptidase,induces apoptosis and cardiomyopathy.J Mol Cell Cardiol.2015,78:154-64.

KITAOKA Y,OGASAWARA R,TAMURA Y,et al.Effect of electrical stimulation-induced resistance exercise on mitochondrial fission and fusion proteins in rat skeletal muscle[J].Appl Physiol Nutr Metab,2015,40(11):1137-1142.

LI J,ZHOU J,LI Y,et al.Mitochondrial fission controls DNA fragmentation by regulating endonuclease G[J].Free Radic Biol Med,2010,49(4):622-631.

LESNEFSKY E J,CHEN Q,HOPPEL C L.Mitochondrial Metabolism in Aging Heart[J].Circ Res,2016,118(10):1593-1611.

MALKA F,GUILLERY O,CIFUENTES-DIAZ C,et al.Separate fusion of outer and inner mitochondrial membranes[J].EMBO Rep,2005,6(9):853-859.

MARUNOUCHI T,TANONAKA K.Cell Death in the Cardiac Myocyte[J].Biol Pharm Bull,2015,38(8):1094-1097.

MOLINA A J,BHARADWAJ M S,VAN HORN C,et al.Skeletal muscle mitochondrial content,oxidative capacity,and Mfn2expression are reduced in older patients with heart failure and preserved ejection fraction and are related to exercise intolerance[J].JACC Heart Fail,2016,4(8)636-645.

ONG S B,SUBRAYAN S,LIM S Y,et al.Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury[J].Circulation,2010,121(18):2012-2022.

PICARD M,GENTIL B J,MCMANUS M J,et al.Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle[J].J Appl Physiol,2013,115(10):1562-1571.

QI Z,ZHANG Y,GUO W,et al.Increased Insulin Sensitivity and Distorted Mitochondrial Adaptations during Muscle Unloading[J].Int J Mol Sci,2012,13(12):16971-16985.

SHARP W W,FANG Y H,HAN M,et al.Dynamin-related protein 1(Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury:Therapeutic benefits of Drp1inhibition to reduce mitochondrial fission[J].FASEB J,2014,28(1):316-326.

TAGUCHI N,ISHIHARA N,JOFUKU A,et al.Mitotic phosphorylation of dynamin-related GTPase Drp1participates in mitochondrial fission[J].J Biol Chem,2007,282(15):11521-11529.

TONDERA D,GRANDEMANGE S,JOURDAIN A,et al.SLP-2is required for stress-induced mitochondrial hyperfusion[J].EMBO J,2009,28(11):1589-1600.

VEERANKI S,GIVVIMANI S,KUNDU S,et al.Moderate intensity exercise prevents diabetic cardiomyopathy associated contractile dysfunction through restoration of mitochondrial function and connexin 43levels in db/db mice[J].J Mol Cell Cardiol,2016,92:163-173.

WANG K,LIU C Y,ZHANG X J,et al.miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury[J].Cell Death Differ,2015,22(6):1058-1068.

WANG J X,JIAO J Q,LI Q,et al.miR-499regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1[J].Nat Med,2011,17(1):71-78.

WASIAK S,ZUNINO R,MCBRIDE H M.Bax/Bak promote sumoylation of DRP1and its stable association with mitochondria during apoptotic cell death[J].J Cell Biol,2007,177(3):439-450.

ZHANG Z,LIU L,WU S,et al.Drp1,Mff,Fis1,and MiD51are coordinated to mediate mitochondrial fission during UV irradiation-induced apoptosis[J].FASEB J,2016,30(1):466-476.

ZHAO L,ZOU X,FENG Z,et al.Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats[J].Exp Gerontol,2014,56(8):3-12.

Supplements (0)

Cited By

Get Citation

PDF

XML

Article views (2) PDF downloads (0)

Turn off MathJax

Article Contents

Abstract

References

	CAI Meng-xin, QI Wen-pu, XU Zu-jie, TIAN Zhen-jun. 2020: Trx1-attenuated Endoplasmic Reticulum Stress is Involved in Exercise-inhibited Loss of Skeletal Muscle Mass after Myocardial Infarction. China Sport Science, 40(11): 73-83. DOI: 10.16469/j.css.202011008
	HAO Mei-li, XI Yue, TIAN Zhen-jun. 2020: Resistance Exercise Inhibits Cardiomyocyte Apoptosis Through Stimulating the Skeletal Muscle FSTL1 Secretion in Myocardial Infarction Rats and its Mechanisms. China Sport Science, 40(1): 67-78. DOI: 10.16469/j.css.202001007
	LI Tie-ying, ZHANG Ying. 2019: Effects of Apelin Supplement during Aerobic Training on AMPK Activation and Mitochondrial Energy Metabolism in Skeletal Muscle. China Sport Science, 39(1): 55-60,84. DOI: 10.16469/j.css.201901008
	TIAN Zhen-jun, LI Ming-xiao, XI Lei. 2018: The Role and Mechanism of FGF21 as an Exerkines in the Inhibition of Cardiomyocyte Apoptosis by Aerobic Exercise. China Sport Science, 38(12): 35-44,67. DOI: 10.16469/j.css.201812004
	SHI Xiu-chao, CAI Meng-xin, TIAN Zhen-jun. 2016: The Observation and Analysis of Stem Cell Mobilization and Endogenous Cardiomyocyte Proliferation Promoted by Interval Exercise and Granulocyte Colony-stimulating Factor Using Confocal Microscopy and Flow Cytometry in Myocardial Infarction Rats. China Sport Science, 36(4): 68-76. DOI: 10.16469/j.css.201604008
	QIAN Shuai-wei, DING Shu-zhe. 2015: Exercise-mediated Autophagy is a Built-in Mechanism to Regulate Skeletal Muscle Metabolic Homeostasis. China Sport Science, 35(10): 55-65. DOI: 10.16469/j.css.201510008
	ZHANG Zhe, CUI Di, WANG Hai-yan, SUN Yi, DING Shu-zhe. 2015: The Effect of Voluntary Running Wheel Exercise on Mitochondrial Protein Import Machinery（PIM）Components in C57BL/6 Mice Skeletal Muscle. China Sport Science, 35(2): 48-53. DOI: 10.16469/j.css.2015.02.008
	WANG Ping, LI Chun-guang, QI Zheng-tang, DING Shu-zhe. 2014: Roles of c-microRNAs in Exercised-Induced Phenotype Change of Skeletal Muscle. China Sport Science, 34(9): 66-71. DOI: 10.16469/j.css.2014.09.002
	TIAN Zhen-jun, CAI Meng-xin, XING Wei-xin. 2012: The Impact of Aerobic Exercise on Cardiomyocyte Proliferation/Apoptosis and Its Mechanism. China Sport Science, 32(3): 60-66. DOI: 10.16469/j.css.2012.03.008
	WANG Hai-tao, LIU Yu-qian, ZHAO Huan-bin, ZHAO Bin. 2011: Effects of Exercise on SIRT 3 in Mitochondria of Skeletal Muscle. China Sport Science, 31(1): 85-88,97. DOI: 10.16469/j.css.2011.01.013

A Review of Mitochondrial Dynamics in Skeletal Muscle and Cardiomyocyte Affected by Exercise——Research Prospects of Cardiac Mitochondrial Dynamics

Abstract

References

Related Articles

Catalog

A Review of Mitochondrial Dynamics in Skeletal Muscle and Cardiomyocyte Affected by Exercise——Research Prospects of Cardiac Mitochondrial Dynamics

Abstract

References

Related Articles

Catalog

Export File

Citation

Format

Content