Dislocation:Pathophysiological State of the Soaring Incidence of Chronic Diseases in Human——Interactions between Diet-Physical Activity-Genes in the Process of Human Evolution

Substantial evidences showed that the high incidence of chronic diseases in human was related to interactions between genes and environment, but mechanisms of the relationship between them were not fully understood.Based on interactions between diet-physical activitygenes and epigenetic evidences in the process of human evolution, this paper expounded reasons and mechanisms of the soaring incidence of chronic diseases in human from the " matching" view.The results showed that the high incidence of chronic diseases in human resulted from mismatches between biological evolution and cultural evolution of human and dislocations between gene and environment because of mismatch, maladjustment and incompatibility between genotype and diet, physical activity, energy metabolism.Excessive diet and lack of physical activity could contribute to the development of chronic diseases by affecting epigenetic modifications and expression of related genes.Consequently, this paper suggested that restricting caloric intake, increasing physical activities, and matching between lifestyle and genotype could be a strategy to prevent and controll chronic diseases.