Exercise-induced Cardiac Remodeling:Regulation of MiRNA

Long-term moderate intensive training can induce cardiac remodeling, displaying cardiomyocyte hypertrophy and proliferation, cell survival, myocardial angiogenesis, inhibiting myocardial fibrosis and a series of structural remodeling with the adaptive cardiac enlargement. Although a lot of research has been carried out to explore the mechanism of exercise-induced cardiac remodeling, so far, it is not clear. In recent years, the researchers has obtained the expression profiles of micrornas in the process of exercise-induced cardiac remodeling with the help of gene chiptechnology. Some researchers confirmed the key microRNAs using the “gain and loss ” method. miRNA provides a new perspective for the study of the regulation mechanism of exercise-induced cardiac remodeling. In addition, the miRNA showed varying characteristics between exercise-induced cardiac remodeling and pathological cardiac remodeling, thus providing a new evidence for physiologic remodeling interpretation of exercise-induced cardiac remodeling rather than pathological remodeling. The analysis of the changes and mechanism of miRNA in the process of exercise-induced cardiac remodeling can provide new methods and strategies for the prevention and treatment of cardiac diseases by miRNA.