The Immune, Inflammation and Aerobic Capacity Response to Living High-Training High-Training Low under Simulated 3200m Normobaric Hypoxia

Objective: This study was to explore the characteristics of immune response to living hightraining high-training low (HiHiLo) under simulated 3 200 m hypoxia. Method: Twelve female rowers slept in simulated 3 200 m normbaric hypoxia at least eight hours a day and trained under 3200 m hypoxia two times per week for three weeks. The target heart rate of hypoxic training was 140¹60 bpm. After 1 day rest every week, blood was taken from cubital veins to measure different kinds of variables. Repeated measures analysis of variance was used to test differences in different time point. Paired T test was employed to compare the difference between two weeks. Results: 1) During HiHiLo period, WBC count show a significant time effect (P=0.01) . Compared with pre-HiHiLo, WBC count decreased significantly in the 1 st week of HiHiLo. GR%, LY% and MO% had no obvious change. 2) There were a significant time effect both in T% and NK% (P=0.046、0.048) . In the 1 st week of HiHiLo, T% elevated and NK% decreased significantly compared with pre-HiHiLo (P<0.05) . 3) No significant time effect was observed both in the CD4⁺ and CD8⁺. But the ratio of CD4⁺ to CD8⁺ decreased obviously in the 1 st week after 3-week HiHiLo (P<0.05) . 4) No significant time effects were observed in B%, Ig A, Ig M and Ig G during HiHiLo. 5) Plasma CRP kept in a normal range and show an obvious time effect. Compared with the 1 st, 2 nd and post-1 st week of HiHiLo, plasma CRP of the 3 rd week was obviously lower. No significant time effect of plasma IL-6 and TNF-α was observed. 6) After 3-week HiHiLo, the blood lactate reduced significantly in 120 W and 160 W (P=0.001, 0.047) and the heart rate decreased significantly in all three steps (all P<0.01) . Conclusion: 3-week living high-training high-training low under simulated 3200 m normobaric hypoxia in low to middle aerobic intensity training period could improve aerobic capacity of female rowers. But it may lead to immunological stress in the first week. This stress will be alleviated gradually in the next two weeks. During HiHiLo, the inflammation response didn't show significant change. In the first week after HiHiLo completed, the immune function may shift toward suppression.