Effects of Aerobic Exercise on Activation of Neuroglia Cells and Expression of Inflammatory Factors in Aging Rats

The aging mechanism in nervous system is closely related to increased activation of neuroglia cells and progressing neuroinflammation with aging. This study tried to shed some light on relationship between chronic inflammation accumulation and aerobic exercise so as to understand how exercise intervened nervous aging through inflammation. Two exercise-interventions, with and after aging, was used, and expressing level of astrocytes, microglia and TNF-α was tested. Result suggested that exercise with aging can significantly reduced activating level of astrocytes, microglia and expression of GFAP, CD11b and TNF-α, however, no significant reductions were observed when exercise after aging. This showed that exercise could effectively delay aging progression through improving neuroinflammation, and the earlier in age to exercise, the better to delay aging.