The Effect of Exercise on Function of Brown Adipose Tissue and Its Mechanism

This study elaborates the effect of exercise on the function of brown adipose tissue (BAT) and its possible pathway mechanism. The incidence of obesity is increasing and induce many chronic diseases, which is seriously threatening human health. In recent years, the thermogenesis and energy consumption characteristics of BAT has made it widely concerned. With the deepening of research, it was found that activated BAT also has the function of combating the chronic inflammatory state and promoting glycolipid metabolism caused by obesity. All of these make it a new target against obesity and metabolic related diseases. Exercise, as an effective means of reducing fat and weight and preventing chronic diseases, may play a role in promoting health by activating BAT. The specific mechanisms are as follows: Exercise promoting the thermogenesis function of BAT may be related to VEGF signaling pathway, PI3 K-Akt signaling pathway and PPAR signaling pathway; The function of combating the chronic inflammatory state may be related to ErbB signaling pathway, Jak-STAT signaling pathway, TGF-beta signaling pathway and insulin signaling pathway; The function of regulating glycolipid metabolism may be related to PPAR signaling pathway, AMPK signaling pathway and insulin signaling pathway. In conclusion, exercise can promote thermogenesis of BAT, improve anti-inflammatory properties and regulate glycolipid metabolism by regulating multiple signaling pathways.