Current Research Status and Prospects of the Regulation of Innate Immunity by Exercise-mediated Autophagy

Autophagy is a kind of fundamental innate immunity defense.The immune receptors,including sequestasome-like receptors(SLRs),toll-like receptors(TLRs),RIG-I-like receptors(RLRs),nod-like receptors(NLRs),dsRNA-dependent protein kinase(PKR),and pathogen receptor CD46,can identify pathogens and then induce autophagy to resist the invasion of pathogens.The autophagy can also affect the innate immune signaling pathway to further regulate the production of type I interferon,while the innate immune molecules in turn can enhance the role of autophagy to remove pathogens,all of these mechanisms reflect the innate immune defense role of autophagy.In addition,the K63 polyubiquitination of death-associated protein kinase(DAPK),c-jun Nterminal kinase 1(JNK1),high mobility group box-1 protein(HMGB1) and autophagy related protein Becline1 also have regulatory effects on autophagy.Studies have confirmed that exercise regulates autophagy through AMP-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR) pathways,however,whether exercise regulates autophagy through the above immune receptors and related molecules remains to be confirmed,and the role of exercise-induced autophagy in the innate immune response process is still unclear.This study mainly discussed the regulation effect of exercise on innate immunity from the perspective of autophagy,so as to provide new research ideas in investigating the effects of exercise on innate immunity.