Effect and Mechanism of Blood Flow Restriction Combined with Low Load Training on Blood Pressure of Male Spontaneously Hypertensive Rats

To explore the effect and mechanism of blood flow restriction combined with low intensity resistance exercise training on blood pressure in spontaneously hypertensive rats. Four weeks old male spontaneously hypertensive rats were randomly divided into control group, low intensity training group, pressure training group and high intensity training group. 35% ~ 55% 1 RM progressive anti ladder training program was conducted in the low intensity training group; 30% ~ 40% blood flow restriction and 35% ~ 55%1 RM progressive anti ladder training program was conducted in the pressure training group; 55% ~ 75% 1 RM progressive anti ladder training program was conducted in the high intensity training group. After training, the blood pressure, expression of endothelin-1,vascular endothelial growth factor and nitric oxide synthetase were measured. Results:1) compared with the control group and the high-intensity training group, the systolic and diastolic blood pressure were decreased significantly in the pressure training group(P < 0.05); compared with the low-intensity training group, the diastolic blood pressure was decreased significantly in the pressure training group(P < 0.05). 2) compared with the control group, the expression levels of endothelin-1 in the blood was decreased significantly in the pressure training group(P < 0.05), and the expression level of vascular endothelial growth factor and nitric oxide synthetase were increased significantly(P < 0.05); 3) compared with the control group, the expression level of endothelial nitric oxide synthetase in the myocardium was increased significantly in the pressure training group(P < 0.05); 4) in the pressure training group, the systolic pressure was positively correlated with endothelin-1(P < 0.05); the systolic blood pressure was negatively correlated with nitric oxide synthetase, vascular endothelial growth factor and endothelial nitric oxide synthetase(P <0.05). Conclusinon:1) the effect of blood flow restriction combined with low intensity resistance training on blood pressure is better than that of high-intensity resistance training; 2) blood flow restriction combined with low intensity resistance training can increase the expression of vascular endothelial growth factor and nitric oxide synthetase in blood and increase the expression of endothelial nitric oxide synthetase in heart muscle, which result in the improvement of the endothelial cells function and blood pressure.