Effects of Moderate Intensity Resistance Training on Brain Functional Connectivity of Methamphetamine Addicts

Objective: To explore the effects and mechanisms of resistance training on brain health of methamphetamine addicts.Methods: 26 male methamphetamine addicts from the Compulsory Isolation and Rehabilitation Center of Shandong Province were recruited in this study, and the portable fNRIs was used to analyze the immediate effect of a moderate intensity resistance training program and the cumulative effect of 12 weeks continuous resistance training on brain functional connectivity. Results: After one bout of resistance training, the relative concentration of oxyhemoglobin in RPFC and LMC were increased significantly, especially in myogenic activity and neurogenic activity. The 12 weeks of resistance training significantly improved sleep quality and anxiety,which were negatively correlated with the WPCO of heart rate activity related to functional connectivity of brain regions, and negatively correlated with the WPCO of respiratory activity of LPFC-LMC, LPFC-RPFC, LPFC-RMC and RPFC-LMC. In the resting state test of 12-week moderate intensity resistance training, the WPCO values of LPFC-LMC, LPFC-RPFC, LPFC-RMC,RPFC-LMC and RPFC-RMC were significantly higher than that of pre-training in band I and II; in band III, there was no significant difference in the WPCO values of each brain area compared with pre-training; in band Ⅳ, the WPCO value of LPFC-LMC was significantly lower than that of pre-training. Conclusions: Moderate intensity resistance training can significantly activate the left and right prefrontal lobes of methamphetamine addicts, and enhance the connections between different brain regions, especially strengthen the myogenic and neurogenic activities in the motor region of the parietal lobe. Moreover, it can promote the prefrontal and parietal lobes to fully participate in motor control, and improve the relationship between heart rate activity, respiratory activity and myogenic activity in the prefrontal, motor and occipital lobes under resting state, and then reduce the side use of the brain area and strengthen regional synchronization, which can improve the sleep quality, anxiety and depression level.