Reversibility of Inhibition Control Injury in Methamphetamine Addicts:The Research Progress of the Improvement Mechanism of Aerobic Exercise and Its Application

This study aims to summarize the effects and mechanisms of aerobic exercise on methamphetamine(MA) addicts' inhibition control of injury, and investigate the difference in the influence of different variables in aerobic exercise on the inhibitory control of MA addicts. It is suggested that: 1) Inhibition control of injury is the biological basis of withdrawal syndromes such as strong drug craving for methamphetamine addicts, and it is also an important target for addictive behavior regulation; 2) there are two possible mechanisms of aerobic exercise in improving the inhibit control injury of MA addicts, one is the micro-adaptive changes of dopamine, serotonin, brain-derived neurotrophic factor and its receptors in the brain, and the other one is the macrodynamic regulation of brain structure and brain activation levels; 3) exercise is a comprehensive variable with characteristics of the dose of exercise intensity, the diversity of exercise types, and the difference of intervention duration. At present, it is found that the high-intensity and various types of long-term aerobic exercise intervention is more effective to improve the inhibition control damage of MA addicts when the exercise time is controlled. Future research should combine the micro and macro perspectives and strictly control the adjustment variables in exercise intervention, so as to explore more universal and targeted exercise intervention programs in order to investigate the mechanism and benefits of aerobic exercise in improving the inhibitory control of MA addicts.