Acute Effects of High-Intensity Interval Training and Moderate-Intensity Continuous Training on Plasma Glucose,Insulin and Inflammatory Factors Levels in Type 2 Diabetic Men

Objective:To compare the acute effects of highintensity interval training (HIIT) versus moderateintensity continuous training (MICT) on postprandial plasma glucose control and inflammatory factors in type 2 diabetic (T2D) men aged 30-50 years.Methods:14 T2D men (42.6±6.5 years old) underwent a randomized three crossover trial.The three interventions are as follows:HIIT,7×1 min at 90%maximal oxygen uptake (V O_2max)+7×2 min at 30%V O_2max+4 min warming up at 60%V O_2max+5 min cooling at 40%V O_2maxwith cycling;MICT,30 min at 50%V O_2maxwith cycling,and a sedentary control (CON) in the postprandial state.Each intervention had a 10 days wash-out period.Plasma glucose,insulin,TNF-α and IL-6 levels were measured at pre-exercise,postexercise and 1 h post-exercise.Two-way ANOVA with repeated measures were used to compare glucose,insulin,TNF-α and IL-6values among the interventions.Results:Total energy expenditure between the two exercises was not significantly different.Lower plasma glucose levels were observed immediately after exercise in HIIT and MICT than that of CON (P<0.001),the glucose level in HIIT was also lower than that of MICT (P<0.01).Glucose levels in HIIT group was increased at 1 h post-exercise compared to immediately post-exercise (P<0.05),while the decrease (1 h post-exercise minus pre-exercise) of MICT group was more than that of CON group (P<0.01).HIIT and MICT (P<0.01) decreased the insulin levels compared to CON,while no difference was observed between the HIIT and MICT.HIIT (P<0.001) and MICT (P<0.01) increased the TNF-α levels at immediately after exercise but returned to the levels of pre-exercise at 1 h post-exercise.Different exercise types have no obvious effect on IL-6.Conclusion:Both acute HIIT and the matched MICT can lower postprandial plasma glucose and insulin levels in type 2 diabetic men aged 30-50 years,and temporarily increase the level of TNF-α.Compared with MICT,HIIT decreases glucose level greater at immediately post-exercise.