Research Progress on the Role and Molecular Mechanisms of Piezo1 in Exercise Regulating Immunity

Scientific exercise is benefit for health, however, the response targets and specific molecular mechanisms of the body's sensory motor stimuli have not been fully elucidated. The motion sensor Piezo has been shown to respond to a variety of mechanical stimuli, such as touch, pain, and hearing, and plays a key role in the physiological or pathological regulation of the body. The Piezo1channel is activated in response to mechanical stimuli induced by movement, and then regulating downstream signaling pathways via Ca2+. By summarizing the research literatures on Piezo1 channel and exercise regulation of immunity, the regulatory effect of Piezo1 in promoting musculoskeletal immunity, enhancing body resistance and regulating chronic cardiovascular disease and its inflammatory immunity response was investigated. This article focuses on the regulatory mechanism of Piezo1 in musculoskeletal and chronic cardiovascular disease immune response induced by exercise, aiming to provide new ideas for the clinical prevention and treatment of musculoskeletal and cardiovascular-related chronic diseases.