• 国家社科基金自助期刊
  • 中国体育类核心期刊
  • 中国人文社会科学期刊AMI
  • 综合评价(A刊)权威期刊
  • 《中国社会科学引文索引》(CSSCI) 来源期刊
MEI Tao, LI Yan-chun, LI Xiao-xia, YANG Xiao-lin, LI Liang, YAN Bing, HE Zi-hong. 2023: Prediction Model of Bench Press 1RM Resistance Training Effect in Young People Based on GWAS. China Sport Science, 43(4): 61-72. DOI: 10.16469/j.css.202304006
Citation: MEI Tao, LI Yan-chun, LI Xiao-xia, YANG Xiao-lin, LI Liang, YAN Bing, HE Zi-hong. 2023: Prediction Model of Bench Press 1RM Resistance Training Effect in Young People Based on GWAS. China Sport Science, 43(4): 61-72. DOI: 10.16469/j.css.202304006

Prediction Model of Bench Press 1RM Resistance Training Effect in Young People Based on GWAS

More Information
  • Received Date: February 02, 2023
  • Objective: The genome-wide association analysis(GWAS) was used to screen genetic markers associated with resistance training effects of bench press 1RM, then a predictive model of bench press 1RM resistance training effect was constructed by combining with phenotye indicators; in addition, the bioinformatics was used to analyze the possible mechanisms of genetic markers in order to provide references for formulate precise exercise and fitness programs. Methods: 193 non-regular exercise adults completed a 12-week resistance training program, the phenotypic indicators such as bench press 1RM, body composition, and muscle thickness were tested before and after the training intervention. The subjects' DNA was collected, and whole-genome genotyping analysis was performed using the Illumina Infinium CGA-24v1-0 chip. GWAS analysis was conducted using PLINK1.9software, and single-nucleotide polymorphisms(SNPs) affecting bench press 1RM training effect were screened. The mean method was used to calculate the genomics polygenic scores(GPGS) after weighting. The K-mean method was used to cluster the percentage change in bench press 1RM and the forward logistic regression analysis was used to build a comprehensive model for predicting the training effect of genomic-phenotye indicators. HaploReg v4.1, GTEx, and KEGG were used to annotate the SNPs included in the model for biofunctionality. Results: 1) After 12 weeks of resistance training, the mean improvement in bench press 1RM was 36.25%(P<0.01), but the individual variation was significant which was ranging from-31.25% to 176.92%. 2) GWAS showed 35 SNPs were significantly associated with the effect of bench press 1RM resistance training(P<1×10-6), and 7 SNPs were included in the genomics regression model to explain 39.6% of the individual differences in training effect, with rs79726572,rs112183859 and rs77187527 explaining 13.7%, 9% and 8%, respectively; the mean GPGS score after weighting was 3.12(range of variation:-3.93 to 27.21). 3) The initial values of prone push, BMI, right upper limb muscle mass, left trunk muscle mass, and GPGS scores were included in the combined model which was constructed by GPGS and phenotype indicators(AUC=0.952, Jorden index=0.767, cut off value 0.251). 4) Bioinformatic analyses showed that the genes or regulated genes underlying 7 SNPs in the genomic prediction model of bench press 1RM training effect were functionally associated with myogenesis; the regulated genes were enriched in Generic Transcription Pathway, Developmental Biology, Myogenesis and other 37 pathways(P<0.01, FDR<0.01). Conclusions: It is the first study to find 7 genetic markers(rs79726572, rs112183859, rs77187527, etc.) related to bench press 1RM training effect based on GWAS. The established “genome-phenotype” comprehensive prediction model has good predictive ability for bench press 1RM training effect. The SNPs related to bench press 1RM training effect are associated with the biological processes of skeletal muscle growth and development, among which the Myogenesis signaling pathway is worth noting.
  • 梅涛,李晓霞,吴剑,等,2021.力量训练促进健康效果的个体差异预测模型研究[J].体育科学,41(9):35-45.
    ALONSO-AUBIN D A,CHULVI-MEDRANO I,CORTELL-TORMOJ M,et al.,2021.Squat and bench press force-velocity profiling in male and female adolescent rugby players[J].J Strength Cond Res,35(Suppl 1):44-50.
    ALVAREZ-ROMERO J,VOISIN S,EYNON N,et al.,2021.Mapping robust genetic variants associated with exercise responses[J].Int JSports Med,42(1):3-18.
    ANGLERI V,DAMAS F,PHILLIPS S M,et al.,2022.Resistance training variable manipulations are less relevant than intrinsic biology in affecting muscle fiber hypertrophy[J].Scand J Med Sci Sports,32(5):821-832.
    ARAZI H,DAMIRCHI A,ASADI A,2013.Age-related hormonal adaptations,muscle circumference and strength development with 8weeks moderate intensity resistance training[J].Ann Endocrinol(Paris),74(1):30-35.
    BARRY B K,WARMAN G E,CARSON R G,2005.Age-related differences in rapid muscle activation after rate of force development training of the elbow flexors[J].Exp Brain Res,162(1):122-132.
    BENTZINGER C F,WANG Y X,RUDNICKI M A,2012.Building muscle:Molecular regulation of myogenesis[J].Cold Spring Harb Perspect Biol,4(2):45-52.
    BONAFIGLIA J T,PREOBRAZENSKI N,GURD B J,2021.A systematic review examining the approaches used to estimate interindividual differences in trainability and classify individual responses to exercise training[J].Front Physiol,12(3):665-672.
    BOUCHARD C,SARZYNSKI M A,RICE T K,et al.,2011.Genomic predictors of the maximal O(2) uptake response to standardized exercise training programs[J].J Appl Physiol (1985),110(5):1160-1170.
    BRIGATTO F A,LIMA L E M,GERMANO M D,et al.,2022.High resistance-training volume enhances muscle thickness in resistancetrained men[J].J Strength Cond Res,36(1):22-30.
    BULL F C,AL-ANSARI S S,BIDDLE S,et al.,2020.World Health Organization 2020 guidelines on physical activity and sedentary behaviour[J].Br J Sports Med,54(24):1451-1462.
    BULL F C,MASLIN T S,ARMSTRONG T,2009.Global physical activity questionnaire (GPAQ):Nine country reliability and validity study[J].J Phys Act Health,6(6):790-804.
    BUSH W S,OETJENS M T,CRAWFORD D C,2016.Unravelling the human genome-phenome relationship using phenome-wide association studies[J].Nat Rev Genet,17(3):129-145.
    CALDOW M K,THOMAS E E,DALE M J,et al.,2015.Early myogenic responses to acute exercise before and after resistance training in young men[J].Physiol Rep,3(9):178-186.
    CHAL J,POURQUIE O,2017.Making muscle:Skeletal myogenesis in vivo and in vitro[J].Development,144(12):2104-2122.
    CHARBONNEAU D E,HANSON E D,LUDLOW A T,et al.,2008.ACE genotype and the muscle hypertrophic and strength responses to strength training[J].Med Sci Sports Exer,40(4):677-683.
    CLARKSON P M,DEVANEY J M,GORDISH-DRESSMAN H,et al.,2005.ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women[J].J Appl Physiol(1985),99(1):154-163.
    FREIMER N,SABATTI C,2003.The human phenome project[J].Nat Genet,34(1):15-21.
    GAO M,LI X,YANG Z,et al.,2021.circ HIPK3 regulates proliferation and differentiation of myoblast through the mi R-7/TCF12 pathway[J].J Cell Physiol,236(10):6793-6805.
    GAVANDA S,GEISLER S,QUITMANN O J,et al.,2020.Three weeks of detraining does not decrease muscle thickness,strength or sport performance in adolescent athletes[J].Int J Exerc Sci,13(6):633-644.
    HARMON B T,ORKUNOGLU-SUER E F,ADHAM K,et al.,2010.CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance training[J].J Appl Physiol (1985),109(6):1779-1785.
    IZQUIERDO M,HAKKINEN K,IBANEZ J,et al.,2001.Effects of strength training on muscle power and serum hormones in middleaged and older men[J].J Appl Physiol,90(4):1497-1507.
    JACOB I,JONES G,FRANCIS P,et al.,2021.The effect of limb position on measured values of vastus lateralis muscle morphology using B Mode ultrasound[J].Transl Sports Med,4(6):697-705.
    JASSAL B,MATTHEWS L,VITERI G,et al.,2020.The reactome pathway knowledgebase[J].Nucleic Acids Res,48(1):498-503.
    KANAZAWA Y,NAGANO M,KOINUMA S,et al.,2021.Basement membrane recovery process in rat soleus muscle after exercise-induced muscle injury[J].Connect Tissue Res,62(5):519-530.
    KOJIC F,RANISAVLJEV I,COSIC D,et al.,2021.Effects of resistance training on hypertrophy,strength and tensiomyography parameters of elbow flexors:Role of eccentric phase duration[J].Biol Sport,38(4):587-594.
    KOSEK D J,KIM J S,PETRELLA J K,et al.,2006.Efficacy of 3days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs.older adults[J].J Appl Physiol (1985),101(2):531-544.
    LIU D,HE L,ZHANG X,et al.,2018.Establishment and application of food frequency questionnaire method among Chinese[J].Wei Sheng Yan Jiu,47(5):744-755.
    MARTEL G F,ROTH S M,IVEY F M,et al.,2006.Age and sex affect human muscle fibre adaptations to heavy-resistance strength training[J].Exp Physiol,91(2):457-464.
    MARTINS-COSTA H C,LANZA M B,DINIZ R C R,et al.,2022.The effect of different resistance training protocols equalized by time under tension on the force-position relationship after 10 weeks of training period[J].Eur J Sport Sci,22(6):846-856.
    MAYHEW J L,BRECHUE W F,SMITH A E,et al.,2011.Impact of testing strategy on expression of upper-body work capacity and onerepetition maximum prediction after resistance training in college-aged men and women[J].J Strength Cond Res,25(10):2796-2807.
    MAYHEW J L,JOHNSON B D,LAMONTE M J,et al.,2008.Accuracy of prediction equations for determining one repetition maximum bench press in women before and after resistance training[J].J Strength Cond Res,22(5):1570-1577.
    MILLER R M,FREITAS E D,HEISHMAN A D,et al.,2019.Maximal power production as a function of sex and training status[J].Biol Sport,36(1):31-37.
    MINNOCK D,ANNIBALINI G,LE ROUX C W,et al.,2020.Effects of acute aerobic,resistance and combined exercises on 24-h glucose variability and skeletal muscle signalling responses in type 1diabetics[J].Eur J Appl Physiol,120(12):2677-2691.
    NUNES J P,PINA F L C,RIBEIRO A S,et al.,2021.Responsiveness to muscle mass gain following 12 and 24 weeks of resistance training in older women[J].Aging Clin Exp Res,33(4):1071-1078.
    OBIKANE Y,TOYONO T,KOKABU S,et al.,2021.Myogenic differentiation 1 and transcription factor 12 activate the gene expression of mouse taste receptor type 1 member 1[J].J Oral Biosci,63(4):420-428.
    PESCATELLO L S,ARENA R,RIEBE D,et al.,2014.ACSM’s Guidelines for Exercise Testing and Prescription[M].Philadelphia:Lippincott Williams&Wilkins.
    PESCATELLO L S,KOSTEK M A,GORDISH-DRESSMAN H,et al.,2006.ACE ID genotype and the muscle strength and size response to unilateral resistance training[J].Med Sci Sports Exer,38(6):1074-1081.
    PIETROSEMOLI N,MELLA S,YENNEK S,et al.,2017.Comparison of multiple transcriptomes exposes unified and divergent features of quiescent and activated skeletal muscle stem cells[J].Skelet Muscle,7(1):28-39.
    POLITO M D,PAPST R,GOESSLER K,2021.Twelve weeks of resistance training performed with different number of sets:Effects on maximal strength and resting blood pressure of individuals with hypertension[J].Clin Exp Hypertens,43(2):164-168.
    PSILANDER N,DAMSGAARD R,PILEGAARD H,2003.Resistance exercise alters MRF and IGF-I m RNA content in human skeletal muscle[J].J Appl Physiol (1985),95(3):1038-1044.
    RHEA M R,ALVAR B A,BURKETT L N,et al.,2003.A meta-analysis to determine the dose response for strength development[J].Med Sci Sports Exer,35(3):456-464.
    RIBEIRO B,FORTE P,VINHAS R,et al.,2022.The benefits of resistance training in obese adolescents:A systematic review and metaanalysis[J].Sports Med Open,8(1):109-117.
    SANTOS A R,LAMAS L,UGRINOWITSCH C,et al.,2015.Different resistance-training regimens evoked a similar increase in myostatin inhibitors expression[J].Int J Sports Med,36(9):761-768.
    SCHIAFFINO S,DYAR K A,CALABRIA E,2018.Skeletal muscle mass is controlled by the MRF4-MEF2 axis[J].Curr Opin Clin Nutr Metab Care,21(3):164-167.
    SCHWARTZ J,OH P,TAKITO M Y,et al.,2021.Translation,cultural adaptation,and reproducibility of the Physical Activity Readiness Questionnaire for everyone (PAR-Q+):The Brazilian Portuguese version[J].Front Cardiovasc Med,8(23):712-723.
    SHAILENDRA P,BALDOCK K L,LI L S K,et al.,2022.Resistance training and mortality risk:A systematic review and meta-analysis[J].Am J Prev Med,63(2):277-285.
    SILVA P R,NASCIMENTO D D C,IV D E S N,et al.,2021.Effects of resistance training on muscle quality index,muscle strength,functional capacity,and serum immunoglobulin levels between obese and non-obese older women[J].Int J Exerc Sci,14(7):707-726.
    SOUZA R W A,AGUIAR A F,VECHETTI-JUNIOR I J,et al.,2014.Resistance training with excessive training load and insufficient recovery alters skeletal muscle mass-related protein expression[J].JStrength Cond Res,28(8):2338-2345.
    SUN L,TRAUSCH-AZAR J S,CIECHANOVER A,et al.,2007.E2Aprotein degradation by the ubiquitin-proteasome system is stage-dependent during muscle differentiation[J].Oncogene,26(3):441-448.
    TAYLOR M V,HUGHES S M,2017.Mef2 and the skeletal muscle differentiation program[J].Semin Cell Dev Biol,72:33-44.
    THOMAS S,READING J,SHEPHARD R J,1992.Revision of the Physical Activity Readiness Questionnaire (PAR-Q)[J].Can JSport Sci,17(4):338-345.
    VILCHINSKAYA N,ALTAEVA E,LOMONOSOVA Y,2022.Gaining insight into the role of Fox O1 in the progression of disuse-induced skeletal muscle atrophy[J].Adv Biol Regul,85(4):100-114.
    WALSH S,KELSEY B K,ANGELOPOULOS T J,et al.,2009.CNTF1357 G->A polymorphism and the muscle strength response to resistance training[J].J Appl Physiol (1985),107(4):1235-1240.
    WANG M H,CORDELL H J,VAN STEEN K,2019.Statistical methods for genome-wide association studies[J].Semin Cancer Biol,55(12):53-60.
    WU M,WEI Y,LV J,et al.,2022.Associations of muscle mass,strength,and quality with all-cause mortality in China:A population-based cohort study[J].Chin Med J (Engl),82(11):110-124.
    YANG X,LI M,JI Y,et al.,2022.Changes of gene expression patterns of muscle pathophysiology-related transcription factors during denervated muscle atrophy[J].Front Physiol,13(7):923-933.
    YOO J,KIM B H,KIM S H,et al.,2016.Genetic polymorphisms to predict gains in maximal O2 uptake and knee peak torque after a high intensity training program in humans[J].Eur J Appl Physiol,116(5):947-957.
    ZAMMIT P S 2017.Function of the myogenic regulatory factors Myf5,Myo D,Myogenin and MRF4 in skeletal muscle,satellite cells and regenerative myogenesis[J].Semin Cell Dev Biol,72:19-32.
    ZEMPO H,MIYAMOTO-MIKAMI E,KIKUCHI N,et al.,2017.Heritability estimates of muscle strength-related phenotypes:A systematic review and meta-analysis[J].Scand J Med Sci Sports,27(12):1537-1546.
  • Related Articles

  • Cited by

    Periodical cited type(3)

    1. 朱珊珊. 体育运动中膝关节力的机器学习评估方法研究. 兰州文理学院学报(自然科学版). 2024(03): 100-104 .
    2. 潘新亮,赵晨曦,陈健豪,隋洪涛,严翊. 运动科学中的多组学应用前景:运动组学. 北京体育大学学报. 2023(11): 52-63 .
    3. 王芳媛,郑慧芳,孙平,陈楠,夏小慧. PRKAA2基因SNP与HIIT干预心肺耐力及糖脂代谢敏感性的关联性研究. 北京体育大学学报. 2023(11): 82-91 .

    Other cited types(0)

Catalog

    Article views (9) PDF downloads (3) Cited by(3)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return