Translational Exercise Medicine: From the Perspective of Molecular Mechanobiology to Proactive Health

Exercise has always played an essential role in promoting health and preventing diseases. However, the molecular and cellular mechanisms behind these benefits are still not fully understood despite of a large body of research evidences. Therefore, it is important to enhance our understanding of molecular and cellular mechanisms and implement those knowledges in medical and health practices. Discovering the link between specific types of exercise and their adaptations is a challenge in the exercise and life science. However, system biology provides a new perspective that helps to establish personalized lifestyle intervention programs.New biological concepts and biotechnological discoveries, such as PIEZOs, autophagy, and the microbiome, are revolutionizing our understanding of how movement(force signal stimuli) affects human systems. This article summarizes the current challenges in sports and exercise research and presents personal views for future research that can contribute to the development of translational exercise medicine.